Sonication time required to achieve a lesion volume of 50 mm3 (1.3 mm in radial direction and 14 mm in axial direction) for mNPs (concentrations of 0.0047%, 0.047%, and 0.0625%*), gNPs (0.0625% and 0.125%), and no NPs (0%) for 5.2, 9.2, and 14.5 W acoustic powers. The values for 0.0625% mNPs concentration have been calculated using the extrapolated temperature data (*). Calculations for each point have been conducted in triplicate (n = 3). Y-axis is in logarithmic scale.